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. 2022 Mar 29;9:597–610. doi: 10.1016/j.toxrep.2022.03.032

Fig. 5.

Fig. 5

Spinal cord pathology in EAE mice exposed to various concentrations of CS. (a) Representative images of spinal cord sections labeled with DAPI (white) and FluroMyelin (red) from naïve control (left) and EAE (right) mice are presented. (b) Total number of lesions are presented as the median ± MAD for naïve control and EAE mice exposed to different concentrations of CS. (c) Statistical analysis of total number of lesions in the spinal cord, indicating a general increase in the number of lesions in EAE mice exposed to the low or medium concentration of CS. Abbreviations: S = sham, L = CS Low, M = CS Med, H = CS High. Statistical significance: *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. n = 8 mice per group, except n = 7 in the 6-week CS Low, n = 10 in the 6-week CS Med, and n = 9 in the 6-week CS High groups (Supplemental Table 1). CS: cigarette smoke; EAE: experimental autoimmune encephalomyelitis; MAD: mean absolute deviation; DAPI: 4′,6-diamidino-2-phenylindole.