Table 2.

Statistically significant changes in serum biochemical markers.

Panel	Blood chemistry parameters	Changes due to EAE	Changes due to smoke exposure	Changes due to smoke exposure (naïve control)	Changes due to smoke exposure (EAE)
Liver function	Total protein	3% ↓ w4**	5% ↑ M w4** 5% ↑ H w4**	8% ↑ M w4***	5% ↑ H w4*
	Albumin	8% ↓ w4*** 4% ↓ w6***	8% ↑ H w2* 6% ↑ M w4** 9% ↑ H w4***
	Globulin	7% ↑ w4*** 6% ↑ w6**	8% ↓ H w6**	14% ↑ M w4**
	Total bilirubin
	Alkaline phosphatase	47% ↓ w4*** 13% ↓ w6**	27% ↓ H w2***		38% ↑ M w4***
	Alanine aminotransferase	32% ↓ w4**
	Aspartate aminotransferase
Energy metabolism	Cholesterol	13% ↓ w4*** 10% ↓ w6*		12% ↑ M w4* 15% ↑ H w4*
	Triglyceride	35% ↓ w6***	58% ↑ H w4**	275% ↑ H w4***
	Glucose	42% ↓ w4*** 13% ↓ w6***
Renal function	Creatinine	16% ↓ w4*** 16% ↓ w6**	23% ↑ H w4*	45% ↑ M w4** 51% ↑ H w4***
	Urea
Electrolytes	Chloride		2% ↓ M w4* 3% ↓ H w4*** 2% ↑ L w6 *
	Sodium		1% ↑ L w4 * 1% ↑ M w4 * 1% ↑ H w4**
	Potassium	8% ↓ w4*** 7% ↑ w6 *
Minerals	Calcium		5% ↑ M w4*** 6% ↑ H w4***
	Inorganic phosphate

Remarks:

Up arrows represent percent increase and down arrows represent percent decrease relative to sham or naïve controls.

Abbreviations: S = sham; L = CS Low; M = CS Med; H = CS High; w2 = 2-week; w4 = 4-week; w6 = 6-week. Statistical significance: *p ≤ 0.05, * *p ≤ 0.01, and * **p ≤ 0.001.