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. 2022 Mar 22;10:878027. doi: 10.3389/fcell.2022.878027

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Copyright © 2022 Poschmann, Bahr, Schrader, Stejerean-Todoran, Bogeski and Stühler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High-confident secretomes and the human secretome. (A) By means of comparative secretomics approach we were able to generate lists of high-confident secreted proteins of NHDF, MSC and A549 cells including 72–88% of proteins which were predicted to be secreted (Poschmann et al., 2021). (B) Our prediction tool OutCyte was used to estimate the number of candidates LLSP in the human secretome to 3,475 (Zhao et al., 2019). LLSP: leaderless secreted proteins. SP proteins: signal peptide containing proteins. OC: OutCyte score. TM proteins: transmembrane proteins.