FIGURE 2.

DKI mice have increased respiratory exchange ratio (RER) and carbohydrate (CHO) oxidation rates during exercise calorimetry experiments. Respiratory gases (VO₂ and VCO₂) were measured every min and used to calculate RER, total energy expenditure (TEE), and substrate utilization during exercise calorimetry treadmill running at 60% of individual maximal running speed. Data presented are the average over the final 5 min of exercise. (A) VO₂; (B) TEE; (C) RER; (D) CHO oxidation rates; (E) Fat oxidation rates; (F) Percent contribution of fat and CHO oxidation rates to TEE. Male mice, 17–20 weeks, n = 11–13. *p < 0.05.