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. 2022 Mar 22;13:859246. doi: 10.3389/fphys.2022.859246

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Copyright © 2022 Janzen, Whitfield, Murray-Segal, Kemp, Hawley and Hoffman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Maximal running speed at a 5° incline is positively correlated with skeletal muscle glycogen utilization following maximal running in WT but not DKI mice. (A) Correlation between maximal running speed and change in liver glycogen was not significant in either WT or DKI mice. (B) WT mice display a significant positive correlation between maximal running speed and change in skeletal muscle glycogen between the rested state and following maximal treadmill running, which was not observed in DKI mice. Male mice, 17–20 weeks, n = 8–9. *p < 0.05.