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. 2022 Mar 17;25(4):104098. doi: 10.1016/j.isci.2022.104098

Figure 3.

Figure 3

Gene set enrichment analysis (GSEA) plots comparing infected organoid populations to mock

GSEA using the hallmark gene set on a list of all differentially expressed genes with fold change ± 3 and adj p value < 0.05.

(A) Hallmark interferon alpha response enrichment plots and corresponding heatmaps from GFP (+) vs. Mock and GFP (Low) vs. Mock, respectively.

(B) Additional enrichment plots and heatmaps (20 representative genes each) from GSEA comparing GFP (+) vs. Mock revealing significant de-enrichment in GFP (+) groups. A normalized enrichment score (NES) and normalized p value (NOM p value) for each plot are shown below; a cutoff of NOM p value < 0.05 was used to establish significance (for full GSEA analysis details see Table S4).