REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit polyclonal anti HES1	Invitrogen	PA5-28802
Chicken polyclonal anti Tuj1	GeneTex	GTX85469
Mouse monoclonal anti UL44	Virusys	CA006-100
Mouse monoclonal anti IE1	Shenk Lab	Clone 1B12
Mouse monoclonal anti IE2	Shenk Lab	Clone 3A9
Mouse monoclonal anti pp28	Shenk Lab	Clone 10B4-29
Mouse monoclonal anti pp65	Shenk Lab	Clone
Mouse monoclonal anti pp71	Shenk Lab	Clone 2M10-9
Rabbit polyclonal anti SOX2	Millipore Sigma	AB5603
Bacterial and virus strains
TB40/EeGFP	Goodrum Lab
TB40r mGFP-IE-FKBP BAC	Borst Lab
Chemicals, peptides, and recombinant proteins
Shield-1	Aobious	AOB1848
Human EGF	Miltenyi Biotec	130-097-749
Human bFGF	StemCell Technologies	78003
Heparin	Millipore Sigma	H5152
Critical commercial assays
RNA Screentape	Agilent	5067-5576
NEBNext Poly(A) mRNA Magnetic Isolation Module	New England Biolabs	E7490L
NEBNext Library Quant Kit for Illumina	New England Biolabs	E7630L
DNA Screentape	Agilent	5067-5582
NextSeq PhiX Control Kit	Illumina	FC-110-3002
NextSeq 500/550 High Output Kit v2.5 (75 Cycles)	Illumina	20024906
Reverse Transcription Kit	Promega	A3500
Pierce BCA	Thermo Fisher Scientific	23225
STEMdiff Cerebral Organoid Kit	StemCell Technologies	08570
STEMdiff Cerebral Organoid Maturation Kit	StemCell Technologies	08571
DNeasy Blood and Tissues Kit	Qiagen	69504
Power SYBR Green PCR Master Mix	Thermo Fisher Scientific	4367659
Deposited data
Manuscript - BioRxiv	This paper	https://doi.org/10.1101/2021.08.01.45465
Raw and Analyzed Data - GEO	This paper	ID# GSE193759
Experimental models: Cell lines
Human iPSC WT 4.2 Line
Human iPSC WT 21.8 Line
Oligonucleotides
Primers for XX, see Table S7	This paper	N/A
Software and algorithms
Ingenuity Pathway Analysis	Qiagen	https://qiagen.pathfactory.com
Basepair Tech		https://www.basepairtech.com
Gene Set Enrichment Analysis	UC San Diego - Broad Institute	https://www.gsea-msigdb.org/gsea/index.jsp
Flowjo		https://www.flowjo.com