Table 6.

Comparison of different algorithms and software for retinal vessel analysis.

	IVAN	SIVA	VAMPIRE	QUARTZ	SIVA-DLS	RMHAS (ours)
Processing time	20 min	25 min	-	53.57s	A few seconds	<2 s
Kind	Semi-automatic	Semi-automatic	Semi-automatic	Automatic	Automatic	Automatic
ROI	Standard	Standard + Extended	Whole fundus	Whole fundus	Standard + Extended	Standard + Whole fundus
Algorism	ML	ML	ML	ML	DL	DL
AVR	√	√	√	√	√	√
Mean vessel diameter	√	√	√	√	√	√
Length-diameter ratio	×	√	×	√	×	√
Vessel tortuosity	×	√	√	√	×	√
Branching coefficients	×	√	√	×	×	√
Branching angle	×	√	√	√	×	√
Angular asymmetry	×	√	×	×	×	√
Asymmetry ratio	×	√	×	×	×	√
Junctional exponent deviation	×	√	×	×	×	√
Fractal dimension	×	√	√	×	×	√
Hierarchical vessel tree	×	×	×	×	×	√
Year	2004	2010	2011	2015	2020	2021

ROI, region of interest; AVR, artery to vein ratio.