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. 2022 Apr 1;219(5):e20211906. doi: 10.1084/jem.20211906

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© 2022 Quattrocelli et al.

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Figure S3. — Additional supporting data related to Fig. 5. (A) Validation of dorsomorphin and AMPKinone effects on AMPK activity in the muscle through the FRET sensor at 24-h after exposure. (B) Untargeted metabolomics showed that prednisone and AMPKinone (AMPK activation) had additive effects on hexose phosphorylation, pyruvate, TCA cycle intermediates and bioenergetics (NADH/NAD⁺; ATP/ADP; creatine phosphorylation). Dorsomorphin (AMPK antagonist) blunted the prednisone-driven gains. Data verified in at least two independent experiments. n = 3 mice/group. *, P < 0.05; **, P < 0.01; ***, P < 0.001; one-way Welch’s ANOVA with Tukey multiple comparison.