Figure 2. Age of Divergence of Cognitive Scores Associated With Higher Alzheimer Disease Genetic Risk Score (AD-GRS) and Age of Statistically Detectable Associations.

Illustration of age of divergence based on higher (95th percentile) and lower (fifth percentile) AD-GRS. The threshold age at which the AD-GRS begins to influence the population mean of the cognitive measure, as detected by the divergence model for that measure, are displayed with blue arrows. The age at which a t test is significantly different for high vs low AD-GRS for each cognitive measure is displayed with red arrows. The mean age of dementia diagnosis in the UK is displayed with a green arrow. NM indicates numeric memory; PM, pairs matching; and SD, symbol digit substitution.