TABLE 1.
Analysis of LY% in all lung cancer patients
| Training cohort | No. (%) |
Total (n=667) |
p value | |
|---|---|---|---|---|
|
20–50 (n=365) |
<20 (n=302) |
|||
| Basic characteristics | ||||
| Age | 0.002** | |||
| <45 | 32(8.7) | 17(5.6) | 49 | |
| 45–60 | 174(47.7) | 112(37.1) | 286 | |
| >60 | 159(43.6) | 173(57.3) | 332 | |
| Sex | 0.013* | |||
| Male | 229(62.7) | 217(71.9) | 446 | |
| Female | 136(37.3) | 85(28.1) | 221 | |
| Histological subtype | 0.002** | |||
| SCC | 75(20.5) | 94(31.1) | 169 | |
| ADC | 187(51.2) | 151(50.0) | 338 | |
| SCLC | 77(21.1) | 42(13.9) | 119 | |
| Others | 26(7.2) | 15(5.0) | 41 | |
| Stage | 0.001** | |||
| I |
43(1.8) |
14(4.7) | 57 | |
| II | 34(9.3) | 17(5.6) | 51 | |
| III | 86(23.6) | 84(27.8) | 170 | |
| IV | 178(48.8) | 168(55.6) | 346 | |
| Unknown | 24(6.5) | 19(6.3) | 43 | |
| Smoking status | 0.093 | |||
| Never smoking | 176(48.2) | 126(41.7) | 302 | |
| Current or ex‐smoker |
189(51.8) |
176(58.3) | 365 | |
| Differentiation | 0.001** | |||
| Undifferentiated | 234(64.1) | 215(71.2) | 449 | |
| Poor |
43(11.8) |
48(15.9) | 91 | |
| Moderate | 79(21.6) | 32(10.6) | 111 | |
| Well | 3(0.8) | 1(0.3) | 4 | |
| Unknown | 6(1.7) | 6(2.0) | 12 | |
| Metastasis | ||||
| Brain | 0.976 | |||
| No | 329(90.1) | 272(90.1) | 601 | |
| Yes | 36(9.9) | 30(9.9) | 66 | |
| Bone | 0.002** | |||
| No | 314(86) | 232(76.8) | 546 | |
| Yes | 51(14.0) | 70(23.2) | 121 | |
| Liver | 0.045* | |||
| No | 341(93.4) | 269(89.1) | 610 | |
| Yes | 24(6.6) | 33(10.9) | 57 | |
| Adrenal gland | 0.736 | |||
| No | 342(93.7) | 281(93.0) | 623 | |
| Yes | 23(6.3) | 21(7.0) | 44 | |
| Lymph node | 0.180 | |||
| No | 170(46.6) | 125(41.4) | 295 | |
| Yes | 195(53.4) | 177(58.6) | 372 | |
| Intrapulmonary | 0.244 | |||
| No | 324(88.8) | 259(85.8) | 583 | |
| Yes | 41(11.2) | 43(14.2) | 84 | |
| Pleural | 0.000*** | |||
| No | 333(91.2) | 248(82.1) | 581 | |
| Yes | 32(8.8) | 54(17.9) | 86 | |
| Mediastinal | 0.514 | |||
| No | 356(97.5) | 292(96.7) | 648 | |
| Yes | 9(2.5) | 10(3.3) | 19 | |
| Validation cohort | No. (%) |
Total (n=645) |
p value |
|
|---|---|---|---|---|
|
20–50 (n=362) |
<20 (n=283) |
|||
| Basic characteristics | ||||
| Age | 0.826 | |||
| <45 | 28(7.8) | 24(8.5) | 52 | |
| 45–60 | 167(46.1) | 124(43.8) | 291 | |
| >60 | 167(46.1) | 135(47.7) | 302 | |
| Sex | 0.013* | |||
| Male |
237(65.5) |
211(74.6) | 448 | |
| Female | 125(34.5) | 72(25.4) | 197 | |
| Histological subtype | 0.034* | |||
| SCC | 84(23.2) | 87(30.7) | 171 | |
| ADC | 205(56.6) | 132(46.6) | 337 | |
| SCLC | 50(13.8) | 44(15.5) | 94 | |
| Others | 23(6.4) | 20(7.2) | 43 | |
| Stage | 0.000*** | |||
| I | 42(11.6) | 13(4.6) | 55 | |
| II | 40(11.1) | 19(6.7) | 59 | |
| III | 89(24.6) | 71(25.1) | 160 | |
| IV | 159(43.9) | 162(57.2) | 321 | |
| Unknown | 32(8.8) | 18(6.4) | 50 | |
| Smoking status | 0.338 | |||
| Never smoking | 162(44.8) | 116(41.0) | 278 | |
| Current or ex‐smoker | 200(55.2) | 167(59.0) | 367 | |
| Differentiation | 0.000*** | |||
| Undifferentiated | 229(63.3) | 205(72.4) | 434 | |
| Poor | 43(11.9) | 49(17.3) | 92 | |
| Moderate | 87(24.0) | 26(9.2) | 113 | |
| Well | 2(0.5) | 2(0.7) | 4 | |
| Unknown | 1(0.3) | 1(0.4) | 2 | |
| Metastasis | ||||
| Brain | 0.465 | |||
| No | 331(91.4) | 254(89.8) | 585 | |
| Yes | 31(8.6) | 29(10.2) | 60 | |
| Bone | 0.029* | |||
| No | 308(85.1) | 222(78.4) | 530 | |
| Yes | 54(14.9) | 61(21.6) | 115 | |
| Liver | 0.005** | |||
| No | 342(94.5) | 250(88.3) | 592 | |
| Yes | 20(5.5) | 33(11.7) | 53 | |
| Adrenal gland | 0.002** | |||
| No | 357(98.6) | 267(94.3) | 624 | |
| Yes | 5(1.4) | 16(5.7) | 21 | |
| Lymph node | 0.020* | |||
| No | 170(47.0) | 107(37.8) | 277 | |
| Yes | 192(53.0) | 176(62.2) | 368 | |
| Intrapulmonary | 0.198 | |||
| No | 326(90.1) | 263(92.9) | 589 | |
| Yes |
36(9.9) |
20(7.1) | 56 | |
| Pleural | 0.037* | |||
| No | 324(89.5) | 239(84.5) | 563 | |
| Yes | 38(10.5) | 44(15.5) | 82 | |
| Mediastinal | 0.063 | |||
| No | 358(98.9) | 274(96.8) | 632 | |
| Yes |
4(1.1) |
9(3.2) | 13 | |
*
p < 0.05, **p < 0.01, ***p < 0.001. LY%: lymphocyte percentage; SCC: lung squamous carcinoma; ADC: lung adenocarcinoma; SCLC: small‐cell lung cancer; poor: poorly differentiated; moderate: moderately differentiated; well: well differentiated.