FIGURE 5.

SIRT1 alleviates acute kidney injury and apoptosis. (A) Representative haematoxylin and eosin‐stained (H&E) kidney sections of C57BL/6 mice which underwent LPS administration and were treated with SRT‐1720 or EX‐527 (scale bars, 50μm). (B) Histopathological score of H&E staining of renal tissue. Quantitative analysis of BUN (C), Scr (D), KIM‐1 (E) and NGAL (F) in the different groups. (G‐H) Representative images of the TUNEL staining on kidneys (scale bars, 100 μm) and statistical percentages of TUNEL‐positive cells. (I‐M) Representative Western blots and statistical results of the protein expressions of SIRT1, Bax, Bcl‐2 and cleaved‐caspase3. Each result was replicated in three independent experiments, and all values are the mean ±SD (n = 3). *Significance compared with CON group (*p < 0.05, **p < 0.01). #Significance compared with LPS group (^# p < 0.05, ^## p < 0.01)