Fig. 2.

Inhibition of ceramide kinase increases the closure rate of acute wounds in mice. A: Wound closure rate of 5 mm biopsy wound on dorsum of CERK-KO or WT mice treated with carboxymethyl cellulose (CMC) control (1% CMC) or SYR382141 (60 mg/kg), orally twice daily beginning 1 day post-injury (1 wound per mouse repeated on two separate occasions). B: Graph depicting acute wound closure rate quantified as percent of initial wound size over 10 days. Two-way ANOVA with Dunnett's multiple comparisons test, ∗P < 0.05, ∗∗∗∗P < 0.0001; n = 5 wounds per genotype, 1 per mouse.