Fig. 5.

Inhibition of ceramide kinase enhances 5-HETE and 5-oxo-ETE biosynthesis in acute wounds. A: Heatmap representation of eicosanoid profile of wound tissue harvested 10 days post-injury from WT mice treated with SYR382141 (60 mg/kg) or control (1% CMC) (n = 3 per treatment group; 1 wound sample per mouse). B: Graphical comparison of C1P profile of wound tissue harvested 10 days post-injury (n = 3 per treatment; 1 wound sample per mouse; two-way ANOVA with Šídák's multiple comparisons test). C: Graph depicting eicosanoid profile of wound tissue harvested 10 days post-injury. (∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001; n = 3 per treatment group; 1 wound sample per mouse; two-way ANOVA with Šídák's multiple comparisons test).