TABLE 2.
Adefovir dipivoxil pharmacokinetic parametersa
| Dose (mg/kg) | Measure | Cmax (ng/ml) | C8 (ng/ml) | AUC (ng · h/ml) | t1/2 (h) | Tmax (h) | CL/F (liters/kg/h) | V/F (liters/kg) |
|---|---|---|---|---|---|---|---|---|
| 1.5 | Median | 86 | 42 | 854 | 6.9 | 2.0 | 1.0 | 8.1 |
| Mean | 101 | 54 | 993 | 6.5 | 1.8 | 1.0 | 9.0 | |
| Range | 48–205 | 26–109 | 551–1,622 | 2.3–8.9 | 1–3 | 0.5–1.5 | 1.7–16 | |
| Coef. var. (%) | 54 | 57 | 42 | 36 | 3,651 | 39 | 53 | |
| 3.0 | Median | 104 | 37 | 944 | 4.4 | 1.3 | 1.8 | 11.3 |
| Mean | 133 | 51 | 1056 | 4.0 | 1.4 | 2.9 | 14.1 | |
| Range | 46–280 | 4–150 | 191–2,465 | 0.9–7.6 | 0.5–3.0 | 0.7–8.6 | 1.9–34 | |
| Coef. var. (%) | 68 | 100 | 76 | 58 | 69 | 100 | 85 |
a
These pharmacokinetic parameters were generated after administration of a single dose and were not determined in the context of steady-state conditions. Coef. var., coefficient of variation.