Synthesis of 1,2,4,5-tetrasubstituted imidazole derivatives using the ZSM-11 zeolite (48 h) catalyst under solvent-free conditions^a.

Entry	R1	R2	Product	Yieldb (%)	M.p. (obsd) (°C)	M.p. (lit.) (°C)
1	4-CH3	C6H5	5a	92	184–186	185–187 ref. 58
2	2-OMe	C6H5	5b	94	208–210	207–211 ref. 59
3	C6H5	4-CH3	5c	95	284–285	285–289 ref. 6
4	4-OH	C6H5	5d	92	280–282	282–284 ref. 11
5	4-Cl	C6H5	5e	93	160–161	160–163 ref. 60
6	C6H5	C6H5	5f	95	215–217	216–218 ref. 61
7	4-OCH3	C6H5	5g	92	182–184	183–185 ref. 58
8	4-NO2	4-Me	5h	95	220–222	219–220 ref. 51
9	4Cl	4-OCH3	5i	94	182–184	180–183 ref. 62
10	4Cl	2,4-Dichloro	5j	92	264–66	—

^aReaction conditions: synthesis of 1,2,4,5-tetrasubstituted imidazole derivatives using benzil (1.0 mmol), aldehyde (1.0 mmol), aniline (1.0 mmol), NH₄OAc (3.0 mmol), ZSM-11 zeolite catalyst of time 48 h (0.05 g).

^bIsolated yield in 30 minutes.