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Cardiac function after doxorubicin treatment in WT and Ogg1-KO mice. (a) Survival plot 14 days after WT and KO mice were treated with 15 mg/kg doxorubicin. (b) Representative heart sections stained with haematoxylin and eosin 2 weeks after treatment with doxorubicin in both WT and Ogg1-KO mice. (c and d) Ejection fraction and left ventricle internal diameter measured at baseline, 1 and 2 weeks postdoxorubicin treatment. All values are mean ± SD. n = 3 − 7∗P < 0.05.
