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. 2022 Mar 22;13:860146. doi: 10.3389/fphar.2022.860146

FIGURE 3.

FIGURE 3

The role of autophagy in T cell differentiation. (A) The difference in regulatory T cell (Treg) differentiation between normal CD4+ T cells and autophagy-deficient CD4+ T cells. Autophagy deficiency in Treg causes reduced interleukin (IL) 10 production. (B) The difference in T helper (Th)1 and Th17 differentiation between normal CD4+ T cells and autophagy-deficient CD4+ T cells. Autophagy deficiency in Th1 and Th17 alleviates the production of interferon gamma (IFN-γ) and IL-17. (C) The difference in Th2 differentiation between normal CD4+ T cells and autophagy-deficient CD4+ T cells. Autophagy deficiency in Th2 promotes IL-4, IL-5, and IL-13 production. (D) The difference in Th9 differentiation between normal CD4+ T cells and autophagy-deficient CD4+ T cells. Autophagy deficiency in Th9 promotes IL-9 production.