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. 2022 Feb 2;12(7):4187–4190. doi: 10.1039/d1ra09298g

Screening studies for nonclassical Corey–Chaykovsky ring-closing reactiona.

graphic file with name d1ra09298g-u1.jpg
Entry Base Global yield [ratio 22(a+b)b : 22c]
1 KOH (2.0 equiv.) 95% [76 : 24]
2 KOH (1.0 equiv.) 83% [82 : 18]
3 K2CO3 (1.2 equiv.) 97% [100 : 0]
a

All reactions were performed in CH3CN : MeOH (9 : 1), for 4 hours at room temperature.

b

22(a+b) was obtained in a 73 : 27 dr.