Screening studies for nonclassical Corey–Chaykovsky ring-closing reactiona.
Entry | Base | Global yield [ratio 22(a+b)b : 22c] |
---|---|---|
1 | KOH (2.0 equiv.) | 95% [76 : 24] |
2 | KOH (1.0 equiv.) | 83% [82 : 18] |
3 | K2CO3 (1.2 equiv.) | 97% [100 : 0] |
All reactions were performed in CH3CN : MeOH (9 : 1), for 4 hours at room temperature.
22(a+b) was obtained in a 73 : 27 dr.