TABLE 1.

In vitro assessment of drug interaction AZT–3TC–IND

Parametera	Estimate	95% confidence interval
Econ	98.99	97.80–100.2
IC50,IND	146.9	128.3–165.6
mIND	1.711	1.393–2.030
IC50,AZT	118.4	108.2–128.6
mAZT	12.89	5.576–20.20
IC50,3TC	1,029.0	1,018–1,041
m3TC	68.75	36,90–100.6
αIND,AZT	0.0001301	−0.6191–0.6194
αIND,3TC	0.6881	−0.05189–1.428
αAZT,3TC	0.9692	0.9417–0.9966
αIND,AZT,3TC	8.94	3.434–14.45

^aE_con, effect seen in the absence of drug (percent); IC₅₀, concentration of drug necessary to reduce the HIV turnover by half when used alone (nanomolar); m, slope parameter, corresponding to the rate of rise of effect with increasing drug concentration; α, interaction.