Study	Xu 2006		Flickinger 2001		Erdine 2007
	Number experiencing event n (%)		Number experiencing event n (%)		Number experiencing event n (%)
	Intervention (neuronavigation)	Control (X‐ray guided)	Intervention (2 isocentres GK)	Control (1 isocentre GK)	Intervention (PRF)	Control (CRF)
Total number	26 (100)	28 (100)	43 (100)	44 (100)	20 (100)	20(100)
Mild and moderate paraesthesia or reduced sensation	26 (100)	28 (100)	13 (30.2)	7 (15.9)	20 (100)	0
Dysaesthesia, severe paraesthaesia and anaesthesia dolorosa	0	2 (7.1)	1 (2.3)	0	0	1 (5)
Reduced corneal reflex	0	2 (7.1)	No data available	No data available	No data available	No data available
Corneal keratitis	0	1 (3.5)	No data available	No data available	No data available	No data available
Masseter dysfunction	0	1 (3.5)	No data available	No data available	No data available	No data available
Cerebrospinal fluid leak resolved	0	1 (3.5)	No data available	No data available	No data available	No data available
Transient rise in blood pressure	0	7 (24)	No data available	No data available	No data available	No data available
Severe adverse event (e.g. life‐threatening episodes, hospitalisation, death)	0	0	0	0	0	0
Adverse events leading to cessation of treatment	0	0	0	0	20 (100)	0
Mortality	No mortality	No mortality	No mortality mentioned	No mortality mentioned	No mortality mentioned	No mortality mentioned