Table 3.

Mutually-adjusted hazard ratios of all cases in the primary radiation cohort and surgical cohort.

Primary Radiation			Surgical Cohort
	HR(95% CI)	p-value		HR*(95 % CI)	p-value
Duration of Radiation Therapy (Days)			Duration of Radiation Therapy (Days)
47–53	1		40–46	1
54–60	1.23 (1.19, 1.27)	<0.001	47–53	1.11 (1.04, 1.18)	0.001
61–67	1.33 (1.28, 1.39)	<0.001	54–60	1.34 (1.24, 1.46)	<0.001
68–73	1.5 (1.41, 1.6)	<0.001	61–67	1.47 (1.31, 1.63)	<0.001
74–80	1.65 (1.53, 1.78)	<0.001	68–74	1.34 (1.13, 1.59)	0.001
81 +	1.69 (1.58, 1.81)	<0.001	75+	1.61 (1.37, 1.88)	<0.001
Time to Treatment Initiation (Days)			Time to Treatment Initiation (Days)
<28	1		<28	1
28 to 56	0.98 (0.94, 1.01)	0.231	28 to 56	1.04 (0.98, 1.1)	0.199
56+	1.05 (1.01, 1.09)	0.017	56+	1.01 (0.93, 1.1)	0.78
Radiation Dose			Radiation Dose
<66 gy	1		<60 gy	1
≥66 gy	0.91 (0.88, 0.93)	<0.001	≥60 gy	0.96 (0.91, 1.02)	0.162
			Post-Operative Adjuvant Radiation Time (Days)
--	--	--	<42	1
--	--	--	42 to 48	1.08 (1.00, 1.17)	0.044
--	--	--	49+	1.19 (1.12, 1.27)	<0.001
--	--	--	Margin Status
--	--	--	Negative	1
--	--	--	Positive	1.21 (1.14, 1.3)	<0.001

^*Adjusted for insurance, median income quartile, site, race, T stage, N stage, charlson comorbidity, treatment, age

HR: Hazard Ratio; CI: Confidence Interval