TABLE 1.

PAEs for exponentially growing (log-phase) and nongrowing (lag-phase) bacterial cultures of S. aureus 306/94 (MSSA)

Growth phase	Concn of antibiotic	Exposure time (h)	PAE (h) (range) of:
			QID	VAN	MOX	GEN	ROX	CTX	CRO
Log phasea	1× MIC	1	2.5 (2.0–3.0)	0.5 (0.4–0.8)	0.8 (0.7–1.1)	1.3 (1.0–1.5)	1.2 (1.1–1.4)	0.6 (0.4–0.9)	0.5 (0.5–0.6)
	2× MIC	1	4.0 (3.7–4.3)	0.7 (0.5–0.9)	1.6 (1.1–1.9)	2.2 (1.8–2.8)	1.5 (1.4–1.6)	0.7 (0.5–1.0)	0.7 (0.5–0.8)
	4× MIC	1	5.0 (4.6–5.3)	0.8 (0.6–0.1)	1.9 (2.1–1.7)	2.5 (2.0–3.0)	1.7 (1.4–1.9)	0.9 (0.5–1.1)	0.6 (0.4–0.8)
Lag phaseb	1× MIC	1	0.5 (0.5–0.6)	0.0	0.0	0.0	0.1 (0.0–0.1)	0.0	0.1 (0.0–0.1)
	2× MIC	1	0.7 (0.6–0.7)	0.0	0.1 (0.1)	0.1 (0.1)	0.3 (0.2–0.5)	0.1 (0.0–0.1)	0.0
	4× MIC	1	1.5 (1.1–1.7)	0.1 (0.1)	0.2 (0.0–0.2)	0.1 (0.0–0.1)	0.4 (0.2–0.5)	0.0	0.1 (0.0–0.1)
Lag phaseb	1× MIC	4	1.9 (1.7–2.1)	0.0	0.1 (0.0–0.1)	0.2 (0.1–0.2)	0.4 (0.3–0.5)	0.1 (0.0–0.2)	0.1 (0.0–0.1)
	2× MIC	4	5.7 (5.5–6.0)	0.1 (0.0–0.1)	0.1 (0.0–0.1)	0.2 (0.1–0.3)	0.5 (0.4–0.6)	0.1 (0.1)	0.1 (0.0–0.1)
	4× MIC	4	6.9 (6.7–7.1)	0.1 (0.0–0.1)	0.1 (0.0–0.1)	0.1 (0.0–0.2)	0.4 (0.3–0.4)	0.0	0.1 (0.0–0.2)

^aExperiments were done in triplicate for all antibiotics. 

^bExperiments with QID were done in triplicate, and the experiments with the other antibiotics were done in duplicate.