TABLE 2.

PAEs for exponentially growing (log phase) and nongrowing (lag phase) bacterial cultures of MRSA strains

Growth phase	S. aureus strain	Exposure time (h)	PAE (h) (range) of:
			QID			VAN
			1× MIC	2× MIC	4× MIC	1× MIC	2× MIC	4× MIC
Log phasea	1159/93	1	2.8 (2.5–3.3)	3.5 (3.4–3.8)	4.8 (4.4–5.1)	1.1 (0.9–1.3)	1.2 (0.8–1.5)	1.2 (1.0–1.4)
	1000/93	1	2.3 (2.2–2.7)	2.8 (2.5–3.2)	4.1 (3.8–4.2)	0.8 (0.6–1.0)	0.8 (0.7–0.9)	0.9 (0.8–1.0)
	134/94	1	1.3 (1.0–1.7)	2.5 (2.4–2.7)	3.8 (3.6–4.0)	0.9 (0.7–1.1)	1.0 (0.8–1.1)	1.2 (0.8–1.4)
Lag phaseb	1159/93	1	0.6 (0.5–0.7)	0.8 (0.7–0.9)	1.2 (1.0–1.5)	0.1 (0.0–0.1)	0.2 (0.1–0.2)	0.2 (0.1–0.2)
	1000/93	1	0.5 (0.4–0.5)	0.6 (0.4–0.7)	1.3 (1.2–1.5)	0.0	0.1 (0.0–0.1)	0.2 (0.1–0.2)
	134/94	1	0.4 (0.2–0.6)	0.4 (0.3–0.4)	0.6 (0.4–0.7)	0.1 (0.0–0.1)	0.0	0.1 (0.0–0.1)
Lag phaseb	1159/93	4	2.0 (1.7–2.0)	5.8 (5.3–6.2)	6.2 (6.0–6.5)	0.0	0.2 (0.1–0.3)	0.2 (0.1–0.2)
	1000/93	4	1.7 (1.5–2.0)	4.5 (4.1–5.1)	5.5 (5.0–5.8)	0.1 (0.0–0.1)	0.0	0.1 (0.1)
	134/94	4	0.6 (0.4–0.8)	1.5 (1.0–1.9)	2.4 (2.1–2.8)	0.1 (0.0–0.1)	0.1 (0.0–0.1)	0.1 (0.1)

^aExperiments were done in triplicate. 

^bExperiments were done with QID in triplicate and VAN in duplicate.