Table 2.

TCR amino acid sequences identified to be shared across 12 CeD patients within the Ttet⁺/Tphe⁺ and Ttet⁻/Tphe⁺ subsets

Phenotype	Shared TCRα/TCRβ sequences	Presence and reactivity a)												b) Previously reported dataset of public gluten‐specific TCRs; c) number of CeD patients
		CD2126	CD2135	CD2219	CD2326	CD5028	CD5030	CD5037	CD5038	CD5058	CD5060	CD5063	CD5065
Ttet+/Tphe+	AV4_LVGGSGGYNKLI_AJ4						R2							O, [ 25 ]; 13
	AV41_AVEGGSNYKLT_AJ53													O, [ 25 ]; 10
	BV7‐2_ASSIRATDTQY_BJ2‐3											R1		O, [ 25 ]; 9
	BV7‐3_ASSIRSTDTQY_BJ2‐3							NR1						O, [ 25 ]; 14
	BV20‐1_SASRTSGRAGDEQF_BJ2‐1													O, [ 26 ]; 6
Ttet−/Tphe+	AV9‐2_ALSDQGSSASKII_AJ3*													NO
	AV9‐2_ALSDPTGTASKLT_AJ44													O, [ 25 ]; 4
	AV10_VVSGGYYGGSQGNLI_AJ42													NO
	AV12‐1_VVNPGGGNKLT_AJ10		NR1											NO
	AV20_AVPNAGGTSYGKLT_AJ52	NR1												NO
	AV22_AVEREGAQKLV_AJ54	R3												NO
	AV36_AVGQGAQKLV_AJ54													NO
	AV38‐2_AYRSEQGAQKLV_AJ54													NO
	BV7‐3_ASSQGQDTEAF_BJ1‐1							R1						O, [ 25 ]; 5
	BV7‐3_ASSLTVTDTQY_BJ2‐3		R1											NO
	BV20‐1_SASDSLNTEAF_BJ1‐1*													NO
	BV20‐1_SASRQVADTQY_BJ2‐3							R1						NO

^a) The grey filling represents patients that express the indicated public TCR sequences. Some sequences were expressed by T cell clones (TCCs) that were tested for gluten reactivity. For these sequences, the gluten reactivity is indicated as NR; not reactive or R; reactive followed by the number of TCCs

^b) The rightmost column denotes whether the public sequence have been O; observed or NO; not observed in a collection of previously defined public sequences of gluten‐specific CD4⁺ T cells

^c) TCR‐α, TCR‐β, and paired TCR‐αβ sequences using identical V‐/J‐genes and identical CDR3 amino acid sequences found in the same cell subset of at least two patients were defined as public.