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. Author manuscript; available in PMC: 2022 Apr 5.
Published in final edited form as: Cancer Res. 2021 Jun 3;81(14):3890–3904. doi: 10.1158/0008-5472.CAN-20-2983

Figure 5.

Figure 5.

Intratumoral microbiota drives primary mammary tumor growth through modulation of proliferation and immune infiltrate. A. Uninfected 4T1 tumor volume B. Control diet-derived fecal conditioned media infected 4T1 breast tumor volume over time. C. Lard diet-derived fecal conditioned media infected 4T1 breast volume over time. D. Tumor volume over time of uninfected 4T1 tumor-bearing mice treated with 5 mg/kg LPS weekly. E. Tumor proliferation as determined by Ki67 immunoreactivity. F. Gram-positive bacteria content in 4T1 breast tumors. G. LPS positive bacteria content in 4T1 tumors. H. Infiltrating tumor-associated macrophage content in 4T1 tumors was determined by F4/80 immuno-reactivity. n=6–9.*p<0.05