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. 2022 Mar 22;13:855701. doi: 10.3389/fimmu.2022.855701

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Copyright © 2022 Zheng, Lee, Qi, Wang, Xu, Wu and Mao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The crosstalk of cells in the neuroinflammation. After TBI, the microglia can interact with astrocytes, the oligodendrocyte, neurons, and NG2 cells through several pathways, and the “closed-loop” mechanisms of their communications remain unclear. In addition, the differentiation between the NG2 cells and polydendrocytes or oligodendrocytes is still not clear, and their difference might play a role in neuroinflammation. (black color: settled cell–cell crosstalk mechanisms, red color: possible crosstalk mechanisms need to be certified).