Composition of Box–Behnken design for SA-SLNs-DE formulations and observed values of the studied responses.

No.	A	B	C	PS (nm)	EE (%)
1	100	300	500	112.5	69.67
2	300	300	500	269.5	71.40
3	100	500	500	126.1	74.36
4	300	500	500	129.7	80.49
5	100	400	400	142.7	73.37
6	300	400	400	224.4	76.94
7	100	400	600	95.55	72.24
8	300	400	600	226.3	75.46
9	200	300	400	181.1	87.00
10	200	500	400	111.7	79.35
11	200	300	600	172.9	69.65
12	200	500	600	110.1	79.03
13	200	400	500	165.4	73.61
14	200	400	500	148.6	71.91
15	200	400	500	116.6	74.81
16	200	400	500	122.0	75.11
17	200	400	500	119.3	73.25