TABLE 5.
Top-5 MSEA results for miRNAs representing dendrogram branches A.1 and B.1.
| Dendrogram branch A.1 (n = 250 miRNAs) | |||
| miEAA category* | Subcategory | FDR-adjusted P-valueΨ | No. observed |
| Immune cells | CD14 expressed | 8.7 × 10–4 | 121§ |
| Immune cells | CD15 expressed | 1.9 × 10–3 | 138 |
| Gene ontology** | Lymphocyte proliferation | 3.5 × 10–3 | 15 |
| Immune cells | CD3 expressed | 3.8 × 10–3 | 105 |
| Immune cells | CD56 expressed | 4.9 × 10–3 | 121 |
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Dendrogram branch B.1 (n = 243 miRNAs)
| |||
| miEAA category | Subcategory | FDR-adjusted P-value | No. observed |
|
| |||
| Immune cells | CD14 expressed | 2.0 × 10–3 | 121§ |
| Immune cells | CD15 expressed | 2.3 × 10–3 | 137 |
| Immune cells | CD19 expressed | 2.3 × 10–3 | 103 |
| Immune cells | CD3 expressed | 2.3 × 10–3 | 105 |
| Immune cells | CD56 expressed | 2.3 × 10–3 | 126 |
MiRNA Set Enrichment Analysis (MSEA) was performed on lists of miRNA sorted by Pearson correlation coefficients estimated between PBMC expression levels and mean expression levels across seven brain regions (within each study group).
*Immune cell data from Leidinger et al. (2014) and comprises miRNAs expressed in at least three individuals for respective cell types (CD14+, CD15+, CD19+, CD3+, and CD56+).
**Data from miRWalk 2.0 (Dweep et al., 2011).
ΨAdjustment using Benjamini–Hochberg approach.
§Observed miRNAs for “CD14 expressed” listed in Supplementary Table 3.