Table 4.

Association between TPO-Ab and thyroid immune related adverse effect and subgroup analysis

	Positive TPO-Ab (N = 7)	Negative TPO-Ab (N = 46)	P-value
Presence of thyroid irAE			0.099
Thyroid irAE	5 (71.4%)	16 (34.8%)
No thyroid irAE	2 (28.6%)	30 (65.2%)
Type of thyroid irAE
Newly developed overt hypothyroidism	2 (28.6%)	12 (26.1%)	1.000
Worsened hypothyroidism	3 (42.9%)	1 (2.2%)	0.006
Subclinical hyperthyroidism	0 (0%)	3 (6.5%)	1.000

Among 196 study population, TPO-Ab were achieved in 82 patients;

TPO-Ab anti-microsomal-antibody, irAE immune related Adverse Effect