Table 5.

Association between TG-Ab and thyroid immune related adverse effect and subgroup analysis

	Positive Tg-Ab (N = 4)	Negative Tg-Ab (N = 16)	P-value
Presence of thyroid irAE			0.591
Thyroid irAE	3 (75.0%)	8 (50.0%)
No thyroid irAE	1 (25.0%)	8 (50.0%)
Type of thyroid irAE
Newly developed overt hypothyroidism	1 (25.0%)	4 (25.0%)	1.000
Worsened hypothyroidism	2 (50.0%)	1 (6.2%)	0.088
Subclinical hyperthyroidism	0 (0%)	3 (18.8%)	1.000

Among 196 study population, Tg-Ab were achieved in 25 patients

Tg-Ab Thyroglobulin-Antibody, irAE immune related Adverse Effect