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. 2022 Apr 4;12:42. doi: 10.1186/s13578-022-00776-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — Overexpression of UBIAD1 inhibited oxidative stress by restoring mitochondrial dysfunction in OGD/R-mediated ferroptosis in vitro. The levels of oxidative stress in UBIAD1-OE and UBIAD1-siRNA neurons, and corresponding experimental groups. A and J ROS production as detected using DCFH-SA assay. B and K Level of mitochondrial membrane potential in various experimental groups as determined using JC-1 staining. C and L ATP production in various experimental groups as evaluated with the ATP assay kit. D and M The activity of mitochondrial complexes I, II, III, IV, and V in various experimental groups. E, F and N, O The level of total GSH and GSH/GSSG ratio in various experimental groups as determined by GSH assay kit. G and P Changes in SOD production in various experimental groups as detected with the WST-8 assay kit. H and Q The level of MAD generation in various experimental groups as determined with the lipid peroxidation assay kit. I and R The level of T-AOC in various experimental groups as evaluated using ABTS assay kit. N = 3, all data are expressed as the mean ± SD, *P < 0.05, **P < 0.01; CTR + vector-UBIAD-OE group vs. OGD/R + vector-UBIAD-OE group and OGD/R + vector-UBIAD-OE group vs. OGD/R + UBIAD-OE group; CTR + vector-UBIAD-siRNA group vs. OGD/R + vector-UBIAD-siRNA group and OGD/R + vector-UBIAD-siRNA group vs. OGD/R + UBIAD-siRNA group