Fig. 2.

Differentially expressed proteins in CSF of patients with JE. A Association between protein expression (JE/Con ratio) and confidence level. A list of 25 overexpressed proteins with log-rank P value < 0.05 and log₂ (JE/Con ratio) > 1.58 and 36 downregulated proteins with log-rank P value < 0.05 and log₂ (JE/Con ratio) < − 1.58 in JE are included in the box on the left and right. B Biological process of JE upregulated proteins. C Biological process of JE downregulated proteins. D Heat map depicts the relative abundance of signature proteins (log₁₀-transformed FOT). Change types related to these signature proteins are denoted on the left (detailed in Additional file 2: Table S2, Additional file 9: Table S3)