Table 2.

Penalized logistic regression model to predict amiodarone pulmonary toxicity

Variables	Univariate analysis Odds ratios (95% CI)	p value	Multivariable analysis Odds ratios (95% CI)	p value
Gender, male	0.887 (0.436–1.805)	0.741
Age, years*	1.032 (1.002–1.063)	0.039	1.047 (1.010–1.085)	0.013
Current or ex-smoker	1.977 (0.997–3.921)	0.051
Underlying lung disease*	3.779 (1.778–8.033)	0.001	2.703 (1.053–6.935)	0.039
Ventricular arrhythmia*	2.564 (1.299–5.063)	0.007	2.511 (1.146–5.501)	0.021
eGFR	0.996 (0.985–1.008)	0507
Duration of amiodarone use	1.010 (1.004–1.016)	0.002
Daily amiodarone dose	1.001 (0.997–1.005)	0.662
Amiodarone-related thyroid dysfunction	1.481 (0.638–3.436)	0.360
Cumulative dose of amiodarone*	4.556 (1.781–11.653)	0.002	4.762 (1.310-17.309)	0.018

Bold indicates factors that are statistically significant

*Factors that are statistically significant after adjustment for age, gender and smoking history