Table 5.

Effect of each parameter on DCR according to baseline values and to the variation between T1 value (after 1 month of therapy) and T0 value (baseline value). This difference has been indicated as delta value (Δ)

Parameter			Univariate				Two-variable				Multivariablea
Variable	Timepoint	Value	p	OR	Lower OR	Upper OR	p	OR	Lower OR	Upper OR	p	OR	Lower OR	Upper OR
Platelets	Basal	+ 10,000					0.077	1.027	0.997	1.058	–	–	–	–
	Δ	Ref ≤ 25,000					0.043	1.749	1.019	3.001	–	–	–	–
White blood cell count	Basal	+ 100					0.002	1.017	1.006	1.028	–	–	–	–
	Δ	Ref ≤ 1920					< 0.001	4.136	1.927	8.878	0.003	3.422	1.528	7.666
Neutrophils	Basal	+ 100					< 0.001	1.030	1.015	1.044	0.004	1.022	1.007	1.037
	Δ	Ref ≤ 310					0.021	1.850	1.097	3.120	–	–	–	–
Lymphocytes	Basal	+ 100					0.381	0.987	0.957	1.017	–	–	–	–
	Δ	Ref ≥ − 300					0.002	2.621	1.444	4.756	0.074	1.804	0.944	3.446
NL ratio	Basal	+ 1					< 0.001	1.329	1.127	1.568	–	–	–	–
	Δ	Ref ≤ 0.86					0.001	2.779	1.503	5.140	–	–	–	–
PL ratio	Basal	+ 1					0.086	1.003	1.000	1.006	–	–	–	–
	Δ	Ref ≤ 22.85					0.009	2.022	1.191	3.432	–	–	–	–
Age	Basal	+ 1	0.879	1.001	0.983	1.020					–	–	–	–
Sex	Basal	Ref F	0.507	0.845	0.514	1.389					–	–	–	–
Number of metastatic sites	Basal	Ref ≥ 3	0.010	0.519	0.316	0.853					–	–	–	–
LDH	Basal	Ref elevated	0.002	0.419	0.243	0.722					0.032	0.528	0.295	0.946

Statistically significant values in bold

At the Δ timepoint the variables have been dichotomized and the “value” represents the reference category

OR (odds ratio) values are expressed in terms of risk of non-response

^aAfter stepwise selection