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. 2022 Mar 22;12:832765. doi: 10.3389/fonc.2022.832765

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Copyright © 2022 Miao, Zhang, Huang, Zhang, Wang, Tang, Teng and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The structures and conjectures of special CARs (double scFvs). Construction of a TanCAR based on the (A) second-generation CAR, (B) third-generation CAR, (C) fourth-generation CAR (the intracellular domain contains a costimulatory molecule), and (D) fourth-generation CAR (the intracellular domain contains two costimulatory molecules). (E) Construction of the dual-signaling CARs based on the second-generation CAR.