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. 2022 Mar 22;12:832765. doi: 10.3389/fonc.2022.832765

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Copyright © 2022 Miao, Zhang, Huang, Zhang, Wang, Tang, Teng and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Some conjectures about the iCARs. (A) When iCAR and the non-tumor cell surface antigen are combined, acute inhibitory signals are produced, inhibiting the function of CAR 1. (B) Replacing the iCAR with a tandem iCAR. As long as one of the scFvs binds to the corresponding non-tumor cell surface antigen, acute inhibitory signals will be generated. These acute inhibitory signals will inhibit the function of the CAR 1. (C) Combining an iCAR with a TanCAR. The iCAR will also inhibit the function of the TanCAR after being activated.