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. 2022 Mar 22;12:832765. doi: 10.3389/fonc.2022.832765

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Copyright © 2022 Miao, Zhang, Huang, Zhang, Wang, Tang, Teng and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AND-NOT CARs. (A) The synNotch receptor binds to the corresponding tumor antigen (a), causing the expression of b-CAR genes. Subsequently, the newly expressed b-CAR binds to the target antigen (b). Finally, the CAR-T cell is activated. (B) The binding of the OFF-Notch receptor to the corresponding antigen (c) induces the expression of tBID, regardless of whether b-CAR is formed and whether it binds to the corresponding tumor antigen. Apoptosis of the CAR-T cell can be induced by the tBID.