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. 2022 Mar 22;12:832765. doi: 10.3389/fonc.2022.832765

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Copyright © 2022 Miao, Zhang, Huang, Zhang, Wang, Tang, Teng and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Some conjectures about special CARs based on the fourth-generation CARs. (A) The SynNotch receptor binds to the corresponding tumor antigen (a), inducing the expression of b-CAR, which is a fourth-generation CAR. When activated, the CAR-T cell will release extra cytokines. (B) The SynNotch receptor binds to the corresponding tumor antigen (a), which induces the expression of (b + c)-CAR (a tanCAR based on the fourth-generation CAR). When activated, the CAR-T cell releases extra cytokines. (C) The SynNotch receptor has two scFvs connected in tandem, and as long as one scFv binds to the corresponding tumor antigen, it will induce the expression of c-CAR (a fourth generation CAR); when activated, the CAR-T cell will also release extra cytokines.