Table 1.
Comparisons of clinicoradiological characteristics in different microvascular invasion grades.
| Variable | M 0n =252 | M1n =207 | M2n =42 | P-value |
|---|---|---|---|---|
| Age (years) | 52.81 ± 10.56 | 50.99 ± 11.22 | 51.12 ± 11.37 | 0.183 |
| Gender | 0.344 | |||
| male | 210 (83.33%) | 180 (86.96%) | 38 (90.48%) | |
| female | 42 (16.67%) | 27 (13.04%) | 4 (9.52%) | |
| PLT, 10^9/L | 150.25 ± 74.36 | 157.60 ± 71.89 | 158.79 ± 91.23 | 0.528 |
| ALT, IU/L | 62.15 ± 90.40 | 63.92 ± 97.84 | 80.62 ± 110.65 | 0.507 |
| AST, IU/L | 56.57 ± 77.51 | 63.22 ± 92.43 | 65.45 ± 47.28 | 0.625 |
| ALB, g/L | 41.80 ± 5.04 | 41.97 ± 5.02 | 41.69 ± 8.20 | 0.922 |
| TBIL, μmol | 18.39 ± 20.98 | 18.08 ± 9.57 | 18.33 ± 6.67 | 0.979 |
| ALP, IU/L | 113.45 ± 96.19 | 109.72 ± 67.12 | 123.58 ± 86.38 | 0.615 |
| APTT, sec | 25.91 ± 19.23 | 28.09 ± 2.82 | 28.37 ± 7.00 | 0.202 |
| PT, sec | 13.81 ± 12.57 | 11.91 ± 5.17 | 12.15 ± 1.18 | 0.092 |
| INR | 1.01 ± 0.11 | 1.00 ± 0.08 | 1.05 ± 0.11 | 0.02 |
| AFP | 0.005 | |||
| 0, normal | 112 (45.90%) | 70 (34.48%) | 10 (23.81%) | |
| 1, abnormal | 132 (54.10%) | 133 (65.52%) | 32 (76.19%) | |
| Hbs Ag | 0.315 | |||
| 0, Hbs Ag(-) | 38 (15.14%) | 21 (10.34%) | 5 (12.20%) | |
| 1, Hbs Ag(+) | 213 (84.86%) | 182 (89.66%) | 36 (87.80%) | |
| Child-Pugh | 0.045 | |||
| 0, A | 248 (98.41%) | 203 (98.54%) | 39 (92.86%) | |
| 1, B | 4 (1.59%) | 3 (1.46%) | 3 (7.14%) | |
| Cirrhosis | 0.977 | |||
| 0, no | 68 (26.98%) | 56 (27.32%) | 12 (28.57%) | |
| 1, yes | 184 (73.02%) | 149 (72.68%) | 30 (71.43%) | |
| No. of nodes | 0.021 | |||
| 0, 1 | 242 (96.03%) | 190 (91.79%) | 36 (85.71%) | |
| 1, ≥ 2 | 10 (3.97%) | 17 (8.21%) | 6 (14.29%) | |
| Shape | <0.001 | |||
| 0, circle | 151 (59.92%) | 52 (25.12%) | 5 (11.90%) | |
| 1, irregular | 101 (40.08%) | 155 (74.88%) | 37 (88.10%) | |
| Arterial peritumoral enhancement |
<0.001 | |||
| 0, absent | 211 (83.73%) | 136 (65.70%) | 23 (54.76%) | |
| 1, present | 41 (16.27%) | 71 (34.30%) | 19 (45.24%) | |
| Peritumoral hypotensity on HBP |
<0.001 | |||
| 0, absent | 219 (86.90%) | 145 (70.05%) | 16 (38.10%) | |
| 1, present | 33 (13.10%) | 62 (29.95%) | 26 (61.90%) | |
| The maximum length | <0.001 | |||
| 0, ≤5cm | 200 (79.37%) | 125 (60.39%) | 16 (38.10%) | |
| 1, >5cm | 52 (20.63%) | 82 (39.61%) | 26 (61.90%) | |
| Intratumoral hemorrhage | <0.001 | |||
| 0, absent | 181 (71.83%) | 113 (54.59%) | 12 (28.57%) | |
| 1, present | 71 (28.17%) | 94 (45.41%) | 30 (71.43%) | |
| Intratumoral fat | 0.204 | |||
| 0, absent | 214 (84.92%) | 180 (86.96%) | 32 (76.19%) | |
| 1, present | 38 (15.08%) | 27 (13.04%) | 10 (23.81%) | |
| Satellite nodules | <0.001 | |||
| 0, absent | 241 (96.02%) | 186 (89.86%) | 34 (80.95%) | |
| 1, present | 10 (3.98%) | 21 (10.14%) | 8 (19.05%) | |
| Capsule | <0.001 | |||
| 0, absence or incomplete | 71 (28.17%) | 136 (65.70%) | 31 (73.81%) | |
| 1, complete | 181 (71.83%) | 71 (34.30%) | 11 (26.19%) | |
Unless otherwise noted, data are shown as number of patients, with the percentage in parentheses. MVI, microvascular invasion.M 0= no MVI; M1=≤ 5 MVI, and occurred in the adjacent liver tissue area (≤ 1 cm); M2= > 5 MVI, or MVI occurred in the distant paracancerous liver tissue area (> 1cm).
PLT, platelet count; ALT, alanine transarninase; AST, aspertate aminotransferase; ALB, serum albumin; TBIL, serum total bilirubin; ALP, Alkaline phosphatase; APTT, activated partial thromboplastin time; PT, prothrombin time; INR, international normalized ratio; AFP, serum a-fetoprotein; Hbs Ag, hepatitis B surface antigen; HBP, hepatobiliary phase.