Table 1.
Functional annotation analysis of DEGs common to all experimental comparisons
| Biological Process (BP) | ||||
| Term | Count | P Value | Enriched | Genes |
| regulation of cellular process | 13 | 0.0049 | 1.69 | TMOD1, MPP1, PDIA6, SAT1, FOSL2, HSP90B1, DHFR, STIM2, ID1, TAX1BP1, S100A6, RGN, PCBD1 |
| regulation of biological process | 13 | 0.0085 | 1.60 | TMOD1, MPP1, PDIA6, SAT1, FOSL2, HSP90B1, DHFR, STIM2, ID1, TAX1BP1, S100A6, RGN, PCBD1 |
| tetrahydrobiopterin biosynthetic process | 2 | 0.0086 | 214.14 | DHFR, PCBD1 |
| tetrahydrobiopterin metabolic process | 2 | 0.0086 | 214.14 | DHFR, PCBD1 |
| pteridine-containing compound biosynthetic process | 2 | 0.0158 | 116.81 | DHFR, PCBD1 |
| biological regulation | 13 | 0.0179 | 1.50 | TMOD1, MPP1, PDIA6, SAT1, FOSL2, HSP90B1, DHFR, STIM2, ID1, TAX1BP1, S100A6, RGN, PCBD1 |
| cellular homeostasis | 4 | 0.0190 | 6.28 | STIM2, RGN, PDIA6, HSP90B1 |
| pteridine-containing compound metabolic process | 2 | 0.0257 | 71.38 | DHFR, PCBD1 |
| cellular metal ion homeostasis | 3 | 0.0409 | 8.53 | STIM2, RGN, HSP90B1 |
| Cellular Component (CC) | ||||
| Term | Count | P Value | Enriched | Genes |
| extracellular exosome | 6 | 0.0202 | 3.21 | TAX1BP1, S100A6, TARS, PCBD1, PDIA6, HSP90B1 |
| extracellular vesicle | 6 | 0.0206 | 3.19 | TAX1BP1, S100A6, TARS, PCBD1, PDIA6, HSP90B1 |
| extracellular organelle | 6 | 0.0207 | 3.19 | TAX1BP1, S100A6, TARS, PCBD1, PDIA6, HSP90B1 |
| extracellular region | 7 | 0.0281 | 2.49 | TAX1BP1, S100A6, RGN, TARS, PCBD1, PDIA6, HSP90B1 |
| cytoplasm | 11 | 0.0287 | 1.61 | MPP1, TMOD1, STIM2, ID1, S100A6, RGN, TARS, PCBD1, PDIA6, SAT1, HSP90B1 |
| membrane-bounded vesicle | 6 | 0.0439 | 2.64 | TAX1BP1, S100A6, TARS, PCBD1, PDIA6, HSP90B1 |
| Molecular Function (MF) | ||||
| Term | Count | P Value | Enriched | Genes |
| tropomyosin binding | 2 | 0.0136 | 135.43 | TMOD1, S100A6 |
The top biological process (BP), cellular component (CC), and molecular function (MF) gene ontology (GO) terms for differentially expressed genes (DEGs) common across all experimental comparisons and the associated count, p-value, fold enrichment, and involved genes are shown (count > 2, p-value < 0.05, fold enrichment > 1.5)