Table 5.

Summary of Ingenuity Pathway Analysis results for C2 and SR comparison

Network Score	Functions
42	Carbohydrate Metabolism, Energy Production
Regulators in Network	Score	Targets	Functions
MACROH2A1	3	4	Consumption of D-glucose, Binding of lipid, Binding of palmitoyl-coenzyme A
Upstream Regulator	Fold	Molecule Type	Activation z-score	P Value
NFKBIA	−1.596	transcription regulator	−2.377	0.000129
MYC	−1.511	transcription regulator	2.359	1.79E-09
XBP1	1.878	transcription regulator	2.593	1.86E-05

The top three networks (network score > 40) and top three regulator effect networks (consistency score > 0, target number > 3, |z-score| > 2, p-value < 0.05) are shown. The top five activated (z-score > 2) and inhibited (z-score < − 2) upstream regulators and master regulators in causal networks are shown (|fold change| > 1.5, |z-score| > 2, p-value < 0.05). Only upstream regulators and master regulators exhibiting differential expression between C2 and SR groups are displayed