Figure 1.

Simplified schematic depiction of the present self‐optimizing reactor platform. Input variables are delivered to the central SCADA system in a universal format, by an experiment selection algorithm of the operator's choice. The SCADA system calculates the required set points for pumps and other reactor peripherals. After the reaction takes place, spectra are measured inline using PAT, then processed in real‐time using chemometric models to determine reactant concentrations. The concentrations are then further processed by the SCADA system to provide the desired objective values, then returned to the decision algorithm for inclusion to the current model and selection of the next reaction conditions.