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. 2022 Feb 6;9(10):2105466. doi: 10.1002/advs.202105466

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© 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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PBNPs rescue IVDD in rats. A) X‐ray and MRI of rat tail including puncture group, puncture with PBNPs (2 µg) injection group, puncture with PBNPs (0.2 µg) injection group and sham group. Rats were sacrificed 4 weeks after injection. B,C) Statistical chart of DH and ratio of IOD of IVD to IVD area. D) HE and Safranin O‐Fast Green staining. The data were presented using mean ± S.D. * indicates p < 0.05, ** indicates p < 0.01, **** indicates p < 0.0001. The experiments above were repeated five times.