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. Author manuscript; available in PMC: 2022 Apr 5.
Published in final edited form as: J Med Chem. 2022 Feb 22;65(5):3943–3961. doi: 10.1021/acs.jmedchem.1c01778

Figure 3. CHD1Li are potent cytotoxic agents in CRC cell line and patient tumor organoids.

Figure 3.

(A and B) Dose-response graphs of lead CHD1Li, measuring cell viability after 72 h of treatment of isolated M-Phenotype SW620 and HCT116 tumor organoids. (C and D) Dose-response graphs of lead CHD1Li, measuring cell viability after 72 h of treatment of CRC042 and CRC102 patient tumor organoids. The data was normalized to DMSO (vehicle) and is shown as the mean ± SEM of triplicate experiments with technical replicates (n = 3) for each experiment.