TABLE 1.

Agar dilution MICs for 201 pneumococcal isolates

Drug	Penicillin susceptibility of straina	MIC (μg/ml)
		Range	MIC50b	MIC90c
Penicillin	S	≤0.008–0.06	≤0.016	0.03
	I	0.125–1.0	0.25	1.0
	R	2.0–>8.0	2.0	4.0
GAR-936	S	≤0.016–0.125	0.03	0.125
	I	≤0.016–0.125	0.03	0.06
	R	≤0.016–0.125	0.06	0.125
Tetracycline	S	≤0.06–64.0	0.25	32.0
	I	≤0.06–64.0	1.0	64.0
	R	≤0.25–128.0	32.0	64.0
Minocycline	S	≤0.06–16.0	0.06	8.0
	I	≤0.06–16.0	0.25	16.0
	R	≤0.06–16.0	4.0	16.0
Doxycycline	S	0.03–16.0	0.125	8.0
	I	≤0.06–32.0	0.5	8.0
	R	0.125–16.0	4.0	8.0
Amoxicillin	S	≤0.008–0.25	0.016	0.03
	I	≤0.016–2.0	0.125	1.0
	R	0.5–4.0	2.0	2.0
Ceftriaxone	S	≤0.008–1.0	0.016	0.03
	I	≤0.016–2.0	0.25	1.0
	R	0.25–8.0	1.0	2.0
Clarithromycin	S	≤0.016–>128.0	0.03	8.0
	I	≤0.016–>128.0	0.06	>128.0
	R	≤0.016–>128.0	1.0	>128.0
Imipenem	S	≤0.008–0.25	≤0.008	0.016
	I	≤0.008–0.25	0.06	0.25
	R	0.03–0.5	0.25	0.5
Meropenem	S	≤0.008–0.5	0.016	0.03
	I	≤0.016–0.5	0.125	0.5
	R	0.125–2.0	0.5	1.0
Vancomycin	S	≤0.06–0.5	0.25	0.25
	I	≤0.06–0.5	0.25	0.25
	R	0.125–0.5	0.25	0.25

^aS, penicillin susceptible; I, penicillin intermediate; R, penicillin resistant. 

^bMIC₅₀, MIC at which 50% of the isolates tested were inhibited. 

^cMIC₉₀, MIC at which 90% of the isolates tested were inhibited.