TABLE 2.
Microbroth MICs for 12 strains tested by the time-kill method
| Drug | MIC (μg/ml) for straina:
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1(S) | 2(S) | 3(S) | 4(S) | 5(I) | 6(I) | 7(I) | 8(I) | 9(R) | 10(R) | 11(R) | 12(R) | |
| Penicillin | 0.06 | 0.016 | 0.03 | 0.03 | 0.5 | 0.5 | 0.25 | 0.25 | 4.0 | 2.0 | 4.0 | 4.0 |
| GAR-936 | 0.06 | 0.03 | 0.03 | 0.06 | 0.125 | 0.06 | 0.03 | 0.03 | 0.03 | 0.03 | 0.06 | 0.06 |
| Tetracycline | 64.0 | 0.5 | 64.0 | 0.5 | 4.0 | 64.0 | 0.125 | 0.25 | 32.0 | 32.0 | 1.0 | 32.0 |
| Minocycline | 16.0 | 0.125 | 8.0 | 0.125 | 0.5 | 64.0 | 0.06 | 0.06 | 16.0 | 8.0 | 0.25 | 4.0 |
| Doxycycline | 8.0 | 0.25 | 16.0 | 0.25 | 1.0 | 16.0 | 0.06 | 0.125 | 8.0 | 8.0 | 1.0 | 8.0 |
| Amoxicillin | 0.03 | 0.03 | 0.016 | 0.016 | 0.06 | 0.125 | 0.125 | 0.06 | 1.0 | 1.0 | 2.0 | 2.0 |
| Ceftriaxone | 0.06 | 0.016 | 0.016 | 0.016 | 0.125 | 1.0 | 0.06 | 0.06 | 2.0 | 2.0 | 1.0 | 2.0 |
| Clarithromycin | >64.0 | 0.03 | 0.016 | 0.03 | >64.0 | 0.008 | 0.016 | 0.03 | >64.0 | >64.0 | 0.03 | >64.0 |
| Imipenem | 0.008 | 0.008 | 0.008 | 0.008 | 0.03 | 0.06 | 0.03 | 0.03 | 0.25 | 0.25 | 0.5 | 0.25 |
| Meropenem | 0.016 | 0.016 | 0.016 | 0.008 | 0.06 | 0.125 | 0.125 | 0.06 | 1.0 | 0.5 | 1.0 | 1.0 |
| Vancomycin | 0.25 | 0.25 | 0.5 | 0.5 | 0.25 | 0.5 | 0.5 | 0.125 | 0.5 | 0.25 | 0.25 | 0.25 |
a
S, penicillin susceptible; I, penicillin intermediate; R, penicillin resistant.