Table 5.
Haplotype interaction analysis with the covariate gender.
| Haplotype association with response (n=311, adjusted by gender) | P value | ||||||
|---|---|---|---|---|---|---|---|
| BSM1 | FOK1 | APA1 | TAQ1 | Freq | Odds ratio (95% CI) | ||
| 1 | G | C | A | T | 0.2201 | 1.00 | — |
| 2 | A | C | A | C | 0.1852 | 2.46 (1.29-4.71) | .0068 |
| 3 | A | C | A | T | 0.1802 | 0.55 (0.24-1.22) | .14 |
| 4 | G | C | C | T | 0.1699 | 0.52 (0.22-1.25) | .15 |
| 5 | G | C | A | C | 0.0495 | 0.69 (0.16-2.94) | .62 |
| 6 | A | T | A | T | 0.0481 | 0.62 (0.18-2.12) | .44 |
| 7 | A | C | C | T | 0.0413 | 1.95 (0.61-6.19) | .26 |
| 8 | G | T | A | T | 0.0383 | 0.80 (0.20-3.16) | .75 |
| 9 | G | T | C | T | 0.0269 | 0.48 (0.09-2.69) | .41 |
| 10 | A | T | A | C | 0.0182 | 4.84 (0.06-389.27) | .48 |
| Rare | * | * | * | * | 0.0224 | 305 (305-305) | <.0001 |
*
Combined genotypes. Global haplotype association P value=.00024