Table 3.
Results of differential blood cell counts and basic lymphocyte subsets in survivors (groups A – C) and non-survivors (group D) on admission to the hospital and after one week of hospitalization.
| Parameter | Admission | After one week | S vs. NS | Changes over time | ||||
|---|---|---|---|---|---|---|---|---|
| Admission vs. After one week | ||||||||
| S | NS | S | NS | Admission | After one week | S | NS | |
| Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | p value | p value | p value | p value | |
| Leukocytes [cells/nL] | 7.0 (5.1-9.3) | 7.9 (5.4-11.3) | 8.2 (6.0-10.2) | 12.15 (9.4-14.28) | 0.0015 ** | <0.0001 **** | <0.0001 **** | <0.0001 **** |
| Hemoglobin [g/L] | 130.0 (119.0-140.8) | 122.0 (108.0-135.0) | 124.5 (112.8-136.0) | 113 (104-126) | <0.0001 **** | 0.0111 * | 0.0120 * | 0.0014 ** |
| Platelets [cells/nL] | 231.5 (173.0-321.0) | 179.0 (136.0-234.0) | 305.5 (233.5-417.5) | 242 (168.5-297.5) | <0.0001 **** | 0.0029 ** | <0.0001 **** | 0.0153 * |
| Neutrophils [cells/nL] | 5.28 (3.43-7.25) | 6.25 (4.06-9.53) | 5.62 (4,0-7.613) | 10.72 (7.81-12.82) | <0.0001 **** | <0.0001 **** | 0.4994 ns | 0.0001 *** |
| Lymphocytes [cells/nL] | 0.995 (0.67-1.40) | 0.7 (0.45-1.03) | 1.38 (0.91-1.895) | 0.66 (0.46-0.85) | <0.0001 **** | <0.0001 **** | <0.0001 **** | 0.9552 ns |
| Monocytes [cells/nL] | 0.49 (0.350-0.698) | 0.415 (0.278-0.620) | 0.67 (0.47-0.92) | 0.5 (0.35-0.705) | 0.0004 *** | 0.0151 * | <0.0001 **** | 0.1042 ns |
| Eosinophils [cells/nL] | 0.01 (0.0-0.02) | 0 (0-0.02) | 0.05 (0.01-0.11) | 0.03 (0.01-0.1) | <0.0001 **** | 0.4196 ns | <0.0001 **** | 0.0005 *** |
| Basophils [cells/nL] | 0.02 (0.01-0.03) | 0.02 (0.01-0.03) | 0.03 (0.02-0.05) | 0.035 (0.02 – 0.07) | 0.8838 ns | 0.2308 ns | <0.0001 **** | 0.0004 *** |
| CD3+ [cells/uL] | 678 (424.5-984) | 447 (271.3-678) | 1024 (653.8 - 1447) | 396 (289-697) | <0.0001 **** | <0.0001 **** | <0.0001 **** | 0.4950 ns |
| CD19+ [cells/uL] | 111 (64-177.5) | 59 (30-109) | 171 (91.25-269.8) | 68.5 (55.5-164) | <0.0001 **** | 0.0005 *** | <0.0001 **** | 0.0150 * |
| CD4+ [cells/uL] | 431.5 (257.8-625) | 267 (154.5-414.5) | 702 (418-1006) | 269.5 (167.5-443.5) | <0.0001 **** | <0.0001 **** | <0.0001 **** | 0.4223 ns |
| CD8+ [cells/uL] | 178.5 (112.5-272) | 118 (67-204.8) | 231 (153-352) | 115.5 (49.75-182.5) | <0.0001 **** | <0.0001 **** | <0.0001 **** | 0.6083 ns |
| IRI | 2.27 (1.56-3.28) | 1.72 (1.14-2,89) | 2.685 (1.923-3.828) | 3.38 (1.638-4.873) | 0.0001 *** | 0.4664 ns | 0.0010 ** | 0.1036 ns |
| NK [cells/uL] | 145 (90-215) | 125 (61-241) | 136.5 (89.5-213.5) | 76.5 (52.25- 140.5) | 0.0399 * | 0.0012 ** | 0.8671 ns | 0.0090 ** |
Comparisons between survivors and non-survivors on admission and after one week of hospitalization (Mann-Whitney test), longitudinal changes in survivors and non-survivors (Wilcoxon rank-sum test). S, survivors; NS, non-survivors; IQR, interquartile range; ns, not significant, *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001