Table 1.

Transcriptional regulators in uncultured bacteria Candidatus Liberibacter and inhibitors found in surrogate models for screening chemicals targeted the gene.

Transcriptional regulators	Function	Surrogate bacterial models	Inhibitors	References
LdtR	Controlling the expression of nearly 180 genes, distributed in processes such as cell motility, cell wall biogenesis, energy production, and transcription.	Sinorhizobium meliloti, and Liberibacter crescens	Benzbromarone, phloretin, hexestrol etc.	Pagliai et al., 2014; Barnett et al., 2019
PrbP	Regulating gene expression through interactions with the RNA polymerase β-subunit and a specific sequence on the promoter region	Liberibacter crescens and Escherichia coli	Tolfenamic acid	Gardner et al., 2016
VisNR	Regulate the expression of the pilin gene flp3 involved in adhesion and psyllid colonization	Sinorhizobium meliloti	Bortezomib, Chemdiv C549-0604, and Chemdiv D244-0326 etc.	Sourjik et al., 2000; Andrade and Wang, 2019; Barnett et al., 2019
RpoH	Alternative sigma factor mediating stress responses including heat, acid, hydrogen peroxide, stationary phase growth, and envelope disrupting agents	Sinorhizobium meliloti	Rosiglitazone	Mitsui et al., 2004; de Lucena et al., 2010; Barnett et al., 2012, 2019